منابع مشابه
Cellular sensors of feast and famine.
In response to changes in environmental conditions, animals and humans alike can initiate physiological regulatory mechanisms to assure survival. For example, when food is scarce, the body becomes “thrifty”, and conversely, when it is abundant, physiological “unthrifty” mechanisms are initiated. Recent work has uncovered novel cellular mechanisms of fuel sensing that contribute to these shifts ...
متن کاملFeast or famine
Lysosomal storage diseases are metabolic disorders characterized by the accumulation of acidic vacuoles, and are usually the consequence of the deficiency of an enzyme responsible for the metabolism of vesicular lipids, proteins or carbohydrates. In contrast, mucolipidosis type IV (MLIV), results from the absence of a vesicular Ca ( 2+) release channel called mucolipin 1/transient receptor pot...
متن کاملFrequency dependent microbial growth during cycles of feast and famine
In Nature microbial populations are subject to fluctuating nutrient levels. Nutrient abundance fluctuations are important for evolutionary and ecological dynamics in microbial communities since they impact growth rates, population sizes and microbial physiology. Here we use automated continuous-culture devices and single-cell imaging to show that when populations of Escherichia coli are subject...
متن کاملLipids and the heart: neither feast nor famine.
The role of serum lipids in cardiovascular disease risk is well established, and reduction of serum lipid levels is now a cornerstone in the treatment of coronary artery disease. Dysregulation of lipid metabolism is also thought to play a role in the development of heart failure, although the mechanisms behind this are incompletely understood.1 Under normal conditions, the heart is primarily de...
متن کاملWhither the lipid profile: feast, famine, or no free lunch?
A lipid profile (LP) is used in clinical practice to assess risk of cardiovascular disease (CVD) and to guide therapy. The standard LP includes a direct measurement of plasma total cholesterol, triglyceride, and HDL cholesterol concentrations, and derived estimates of LDL cholesterol, non–HDL cholesterol, and lipid ratios (1 ). Expert guidelines recommend that accurate assessment of the LP requ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2002
ISSN: 0021-9738
DOI: 10.1172/jci0216045